Optimal lymph node dissection for gastric cancer: a narrative review.

Furthermore, subgroup analysis showed a trend towards a benefit of D2 dissection in patients with locally advanced gastric cancer > T1 (DSS 55% for D1 vs. 69% for D2 with p = 0.143) and in N + patients (OS rate of 35% for D1 vs. 51% for D2 and DSS rate of 38% for D1 vs. 59% for D2) and in patients with T2-T4 and N+.

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However, in the Italian trial, the authors noted a positive trend in specific survival for patients with T2-T4 or N + tumours in favour of D2 without systematic SPC dissection [ 10 ], confirmed by the 15-year results published in 2021 [ 12 ].

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