GM-1020: a novel, orally bioavailable NMDA receptor antagonist with rapid and robust antidepressant-like effects at well-tolerated doses in rodents.

However, in the second CMS study in WKY rats, the effect of ketamine (10 mg/kg, i.p.) on sucrose intake failed to reach statistical significance, suggesting that this dose in Wistar Han rats is near the MED and at most, is ~1⁄2 a log unit above the MED.

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