Interestingly, genes associated with the dynamic RARαa BSs containing DR1, DR2 or DR5 motifs ( Supplementary Figure S1B ) showed a higher association with up-regulated genes in response to atRA, and none of them had a clear trend towards gene repression ( Supplementary Figure S2C ).
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Rewiring of the epigenome and chromatin architecture by exogenously induced retinoic acid signaling during zebrafish embryonic development.
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