Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices.

In addition, a statistical trend test (SAS procedure REG) was performed to assess a possible dose-related increase of micronucleated cells.

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In the present study, there was a significant trend towards centromere negative micronuclei at the highest concentration of WC/Co, 100 μg/ml in TK6 cells ( Supplementary Data ).

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Moche and colleagues also demonstrated that the WC/Co induced highly significant micronuclei frequency in primary human lymphocytes at 4 hours (80 μg/ml) and 24 hours (20, 40, 60, and 80 μg/ml).

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