Identification and validation of a novel predictive signature based on hepatocyte-specific genes in hepatocellular carcinoma by integrated analysis of single-cell and bulk RNA sequencing.

Previous research in HCC has shown a significant down-regulation of ADH4 mRNA and protein expression in tumor tissues, which shows a highly significant correlation with worse survival [ 38 ].

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While the observed difference did not reach statistical significance, our findings indicated that individuals in the low TMB group exhibited a more favorable prognosis compared to those in the high TMB group (Fig. 8 B).

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