Comprehensive genomic profiling of pulmonary spindle cell carcinoma using tissue and plasma samples: insights from a real-world cohort analysis.

Although not reaching statistical significance, group 1 patients showed a trend toward having more genetic alterations in the RTK/RAS and PI3K pathways ( p = 0.104 and p = 0.611, respectively), while those in group 2 were more likely to carry TP53 mutations and alterations in the HIPPO pathway ( p = 0.184 and p = 0.659, respectively) (Figure 3I ).

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