Impact of Lipid Composition on Vesicle Protein Adsorption: A BSA Case Study.

The calculated key parameters of the phospholipid membranes from molecular dynamics simulations showed a clear trend of both CHOL and DOTAP to decrease Na + interaction with the membrane, which could also contribute to the differential behavior of liposomes relative to the adsorption of BSA, in addition to explaining the observed ζ-potential trend with increasing non-DPPC lipid.

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This suggests that the lack of an overall trend in ζ-potential values in formulations without added salt could be attributed to the stabilizing effect of CHOL alone, with only small effects from the presence of Na + ions in the buffer.

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