Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner.

There was a tendency for higher ultimate force and stiffness in the KO males that received the AAV8-irisin injection, however, this did not reach statistical significance ( Figure 2H ).

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We chose male mice due to the highly significant effect on bone mass and strength we saw in the KO males compared to WT males on a low-calcium diet.

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