At higher temperatures such as 55°C, there was no significant preservation of particle integrity in the AAV6.2FF vector sample formulated in 0.001% PF-68, even after 30 minutes; however, analysis of the average vector genomes over time showed a trend toward greater particle integrity of the AAV6.2FF vector sample formulated in 0.001% PF-68 (Figure S 2 B).
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Analysis of the impact of pluronic acid on the thermal stability and infectivity of AAV6.2FF.
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