siRNA treatment targeting integrin α11 overexpressed via EZH2-driven axis inhibits drug-resistant breast cancer progression.

At three days after the last siRNA drug administration, the tumor size in the si EZH2 -treated group was significantly smaller but still growing, while the tumors in the si ITGA11 -treated group stopped growing and showed a trend toward regression (Fig. 7 A and B).

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Stem Checker analysis revealed highly significant enrichment of stem cell-related genes, Nanog, Oct4, Sox2, Smad2/3/4, and SUZ12, of which SUZ12 was the most significant molecule (Fig. 2 C).

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