The cyan module, related to synaptic signaling, showed a trend towards being lower expressed in the AD group compared to the control group The expression of genes belonging to this module showed inter-donor variability, although most of the AD donors had a reduced expression of these genes (Fig. 4 C).
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Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response.
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