An observational time-series study on the behavioral effects of adjunctive artisanal cannabidiol use by adults with treatment resistant epilepsies.

BMC Neurol · 2024 · PMC11046917 · PMID 38671370

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

highly significantp = 0.000not a probability at all

A highly significant main effect of TIME was found (2df, F = 13.936, p = 0.000).

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almost significantp = 0.054so close (0.05 < p ≤ 0.1)

A main effect of SUBSCALE was almost significant ( p = 0.054).

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a decreasing trendno p-value reported

Although estimated marginal means confirmed a decreasing trend in depression scores over time, this data indicated that ANXIETY decreased more over TIME than DEPRESSION.

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an increasing trendno p-value reported

Importantly, though, the mean levels of metabolites at TIMES 2 and 3 were substantially larger than at TIME 1, and an increasing trend in the mean was apparent for all metabolites over time, confirming that participants added CBD to their treatment regime.

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did not reach statistical significanceno p-value reported

Improvements noted in the experience of depression symptoms did not reach statistical significance.

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