Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström syndrome.

Global Alms1 KO males showed unaltered glycaemic excursion after oral glucose ( Figure 2 H,L), but severe hyperinsulinemia ( Figure 2 N), and MSC-KO mice showed a trend towards increased glucose excursion and insulinemia on oGTT ( Figure 2 L,N).

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MSC KO mice broadly failed to reproduce the pattern of increases in cytokines seen in global KO animals, though female MSC KO mice did show increases in TNF-α and IL-6 of borderline significance.

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