Targeting Molecular Mechanisms of Obesity- and Type 2 Diabetes Mellitus-Induced Skeletal Muscle Atrophy with Nerve Growth Factor.

As a result, the HFS + STZ group showed a significant decrease in phosphorylation levels of Akt while the HFS group only showed a trend ( Figure 3 b, * p < 0.05, HFS + STZ vs.

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It is noteworthy that although NGF administration alleviated translocation of FoxO1 into the nucleus, which regulates transcription of both E3 ligases, the levels of the ligases exhibited an increasing trend compared to the non-treated counterparts.

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