TMT-Based Quantitative Proteomic Analysis Reveals the Key Role of Cell Proliferation and Apoptosis in Intestine Regeneration of <i>Apostichopus japonicus</i>.

Further EdU- or Tunel-based flow cytometry assay and western blotting experiments not only confirmed that during intestinal regeneration, the expression levels of proteins related to cell proliferation showed an increasing trend but also revealed that the expression levels of proteins associated with cell apoptosis experienced a pattern of initially increasing followed by decreasing.

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Similarly, we screened DEPs related to cell apoptosis from the proteome and found that the expression levels of these proteins were not significantly upregulated at normal and 2 dpe levels but showed a trend of first increasing and then decreasing as intestinal regeneration progressed ( Figure 5 E).

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