Although the IC 50 -value of DAES with SO1861 was low at 0.03 nM while the corresponding value for the combination of DE with SO1861 was found to be ten times higher (0.3 nM), the difference between these therapies did not reach statistical significance.
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A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861.
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