Clonal hematopoiesis of indeterminate significance Clonal hematopoiesis of indeterminate potential (CHIP) is a hematologic disorder characterized by age-related acquisition of mutations in hematopoietic stem cells [ 65 ], leading to a clonal myeloid cell population that is associated with increased systemic inflammation [ 66 ].
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Inflammation in heart failure: pathophysiology and therapeutic strategies.
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