Placebo Effects Are Small on Average in the 7.5% CO2 Inhalational Model of Generalized Anxiety.

However, an exploratory analysis showed a trend-level negative relationship between expectations of benefit following conditioning and change in reactivity to CO 2 challenge in the “lorazepam” group in subjective outcome measures only.

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We additionally found a nonsignificant trend association between increased expectations post-conditioning and reduced sensitivity to CO 2 challenge in subjective anxiety and mood measures only (see supplementary Material ).

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