Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1α and nuclear factor erythroid 2-related factor 2.

Our hypoxia protocol although reduced EF and FS in WT mice, this reduction did not reach statistical significance ( Figure 1 A–C ; Supplementary material online , Figure S2J and K ).

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