Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling.

Indeed, the number of Ki67 + proliferating cells was slightly lower in Phgdh fl/fl Cx3cr1 -Cre tumors than in Phgdh fl/fl tumors, although the difference did not reach statistical significance (Fig. 3G ).

also in 111,027 other papers