Observational Dose-Response Meta-Analysis Methods May Bias Risk Estimates at Low Consumption Levels: The Case of Meat and Colorectal Cancer.

For example, some studies showed a positive trend with meat consumption, whereas others showed a negative trend, or highly nonlinear trends ( Supplemental Figures 3–6 ) Comparison of lower consumption DR with all consumption Neither the empirical DR nor 2-stage models fit to the lower consumption data sets showed significant effects of RM or of PM on CRC ( FIGURE 5 , FIGURE 6 ) within the lower consumption range (20 g or less for PM and 56 g or less for RM).

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