Novel anti-inflammatory effects of the IL-1 receptor in kidney myeloid cells following ischemic AKI.

We noted similar induction of kidney injury biomarkers in Myel WT and Myel KO mice at 6 h; however, compared to Myel WT mice, Myel KO mice demonstrated significantly elevated levels of serum creatinine ( Figure 2B ) and blood urea nitrogen (BUN) ( Figure 2C ) at 24 h after I/R injury with a strong trend toward increased injury as measured by histologic injury scoring ( Figures 2D, E ).

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