FOXO1 is a master regulator of memory programming in CAR T cells.

TCF7 did not reach statistical significance in FOXO1 KO experiments and was therefore not included in the FOXO1 regulon; however, regulon score significantly correlated with the TCF7 transcript in patient CAR T cells, suggesting that the regulon is an accurate readout for FOXO1 transcriptional activity (Fig. 5e ).

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