Cells carrying significant asthma variants (rs2305480, rs2305479, rs7216389 and rs9303280) that showed a trend of association towards increased expression of GSDMB also exhibited higher ssGSEA scores for ISGs ( figure 7a –d) when infected with RV.
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Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation.
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