Immunohistochemistry for matrix metalloproteinase 2 (MMP2) as a surrogate marker for tumor cell invasion in mouse tumor tissue showed a trend supportive of the direct relationship between PDE10A levels and glioma tumor cell invasion/migration ( Supplemental Fig.
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Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
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