Evaluation of the antiplasmodial efficacy of synthetic 2,5-diphenyloxazole analogs of compounds naturally derived from Oxytropis lanata.

A robust negative correlation to IC 50 ( r = −0.504) was exhibited by the Number of Hydrogen Bond Donors (NumHDonors), accompanied by a highly significant p -value ( p = 2.56e-04), which was indicative of an association between a higher count of hydrogen bond donors and enhanced compound activity.

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A clear trend was revealed by the SAR analysis, in which the replacement of hydroxyl groups with methoxy or acetyl groups—indicated by red arrows—was found to lead to reduced or increased inhibitory activity, respectively.

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