Acute pharmacodynamic responses to sitagliptin: Drug-induced increase in early insulin secretion in oral glucose tolerance test.

12 reported a 14% decrease in glucagon levels, we observed a highly significant increase in glucagon 2 h after sitagliptin (100 mg) at time 0 of the OGTT compared with the time 0 of the placebo OGTT.

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9 saw a very similar 9% decrease in glucose AUC in response to sitagliptin in healthy volunteers, although it did not reach statistical significance with their sample size ( n = 10).

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