Effects of systemic inflammation on the network oscillation in the anterior cingulate cortex and cognitive behavior.

Results Effects of LPS on IL-6 concentration LPS-treated mice showed a significant increase in IL-6 concentration in the serum ( Fig 3A ) (p = 0.0002) and an increasing trend in the supernatant of the brain tissue, i . e ., the cerebral cortex, including the ACC ( Fig 3B ) (p = 0.177).

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While the interleukin-6 concentration in the serum was evidently higher in LPS-treated mice, the increases in the cerebral cortex interleukin-6 did not reach statistical significance.

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