Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles.

Also, we found that the GFAP immunostained area in the entorhinal cortex negatively correlated with brain weight in the crude analysis ( r = −0.18; P = 0.04) and was borderline significant when we adjusted by age at collection and sex ( r = −0.17; P = 0.06); however, this association was not present in the amygdala.

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Even though they found a trend of association between GFAP and neuropathological lesions of AD, their results did not reach statistical significance.

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