Genetic association of inflammatory marker GlycA with lung function and respiratory diseases.

Specifically, GlycA showed significant inverse genetic correlation with two lung function parameters (FEV1: r g = −0.14 [95%CI: −0.19, −0.09; P = 1.01 × 10 −7 ]; FVC: r g = −0.18 [95%CI: −0.23, −0.13; P = 3.54 × 10 −14 ]) and significant positive genetic correlation with asthma (r g = 0.21 [95%CI: 0.11, 0.31; P = 1.93 × 10 −5 ]) and COPD (r g = 0.31 [95%CI: 0.16, 0.46; P = 6.04 × 10 −5 ]) after controlling for multiple testing ( P < 0.05/30), while GlycA was only marginally significant related with FEV1/FVC (r g = 0.06 [95%CI: 0.01, 0.11; P = 0.02]) and PEF (r g = −0.07 [95%CI: −0.12, −0.03; P = 2.74 × 10 −3 ]).

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