Advancing responsible genomic analyses of ancient mollusc shells.

As for the shell layer test, we observed no significant differences across mapping statistics other than higher 5’ C-to-T rates when processing the outer prismatic shell layer (t-test = −4.81, df = 4, p-value = 0.004), which also showed a trend for lower endogenous DNA content (t-test = 1.98, df = 4, p-value = 0.059; Figs 2 and 3 ; S2 Table ).

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