While not reaching statistical significance, there was a clear trend towards elevated levels of exhausted CD8+ T cells in the PI3K/mTORi‐treated tumours compared to those treated with PI3K/mTORi+PD1i.
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PI3K/mTOR inhibition induces tumour microenvironment remodelling and sensitises pS6<sup>high</sup> uterine leiomyosarcoma to PD-1 blockade.
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