Long-term Pegvisomant Therapy of Acromegaly: Effects on Bone Density, Turnover and Microstructure Using HRpQCT.

J Endocr Soc · 2024 · PMC11074588 · PMID 38715589

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PTH showed a trend to increase early, by 4 weeks, after the start of pegvisomant but was only significantly higher compared to pretreatment at 24 weeks of therapy ( P = .01). 25-hyroxy vitamin D levels also tended to increase early after the start of pegvisomant and were significantly higher than pretreatment at 8 ( P = .05) and 12( P = .01) weeks of therapy.

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