Preclinical development of EXT608, an investigational parathyroid hormone derivative with extended half-life for the treatment of hypoparathyroidism.

In the distal metaphysis, compared with the sham surgery group, animals in the TPTx: vehicle group had a statistically significant increase in trabecular BMD and small increases in total and subcortical/cortical BMD, which did not reach statistical significance ( Figure 6A-C ).

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