Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts.

Bone turnover parameters P1NP and TRAP increased with hyperthyroidism in both Cre-negative and Cre-positive male and female mice, although changes in TRAP levels of euthyroid versus hyperthyroid Cre-positive mice did not reach statistical significance in the male (+31.7%, p = 0.056), but only female cohort (+82.3%) (Fig. 1j, k ; Fig.

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