Evaluation of the immunogenicity of an mRNA vectored Nipah virus vaccine candidate in pigs.

Responses post-boost showed significant inter-animal variability with 4/6 pigs showing clear peptide-specific responses, which meant responses did not reach statistical significance.

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This may be significant since data from a study evaluating the protective efficacy of a HeV sG protein-based vaccine suggested that both antibody and cell-mediated immunity is necessary to protect pigs against henipaviruses ( 23 ).

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