Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS.

6c) and observed a highly significant correlation between epigenetic and chronological age ( R 2 = 0.99, p = 6.2 × 10 –14 ) using the most recent version of the Horvath’s clock that has been trained on blood and skin tissue samples [ 46 ] (Fig. 4 a).

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The basal respiration, representing the energetic demand under basal condition, appeared higher in old dchiOL compared to adult dchiOL, however, the difference did not reach statistical significance (Fig. 2 d).

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