Hyphal Als proteins act as CR3 ligands to promote immune responses against Candida albicans.

albicans , those infected with the als3 Δ/Δ mutant showed a trend towards reduced cytokines and chemokines, including IL-1β, TNF-α, IL-6, IL-10, CXCL1/KC, and CXCL2/MIP-2α, with only the reduction of TNF-α being statistically significant (Fig. 2b and Supplementary Fig. 2b ).

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