From Cell Populations to Molecular Complexes: Multiplexed Multimodal Microscopy to Explore p53-53BP1 Molecular Interaction.

However, the isolation of the population showing the highest amount of each of the three analyzed molecular species revealed a trend in the simultaneous accumulation of all the other components: cells with increased p53 content showed a trend in increasing their transcriptional activity and amount of nucleoplasmic 53BP1 ( Figure 2 a, third dot plot, blue spots), a higher amount of phosphorylated PolII associated with increased p53 and 53BP1 content, and similarly highly positive 53BP1 cells ( Figure 2 b,c, third dot plot, blue spots).

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