a strong trendp = 0.098
In the multivariate Cox regression proportional hazard model, a strong trend could be observed for elevated S100 at baseline (HR 1.78, 95% CI 0.90–3.54, p = 0.098) but not for the high-CCL20 group (HR 1.46, 95% CI 0.77–2.75, p = 0.244) regarding OS ( Table 5 ).