A Systematic Genotoxicity Assessment of a Suite of Metal Oxide Nanoparticles Reveals Their DNA Damaging and Clastogenic Potential.

Fe 2 O 3 Variants Uncoated Fe 2 O 3 NPs (US3160) showed a trend to decrease MN induction at all concentrations tested (potential interference) and induced a significant decrease relative to negative control only at 20 μg/mL, whereas Fe 2 O 3 MPs induced a 1.8-MN-fold increase at the highest concentration of 40 μg/mL ( Figure 8 H).

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With regards to % relative survival, although a decreasing trend was observed at the highest concentration of 20 μg/mL of the uncoated or coated ZnO NPs or 33 μg/mL of ZnCl 2 , none of them induced a statistically significant decrease compared to the matched negative control at 2 or 4 h ( Figure S13A ), the exposure durations used for the comet assay.

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