While they did not observe a statistically significant reduction in OS by Kaplan-Meier analysis, there was a numerical trend towards reduced survival in patients whose tumours demonstrated ZNF331 methylation.
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Evaluating the utility of <i>ZNF331</i> promoter methylation as a prognostic and predictive marker in stage III colon cancer: results from CALGB 89803 (Alliance).
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Furthermore, while patients whose tumours demonstrated ZNF331 promoter hypermethylation and received IFL adjuvant therapy had a numerically shorter DFS and OS, this did not reach statistical significance.