Hepatic arterial infusion of autologous CD34⁺ cells for hepatitis C virus-related decompensated cirrhosis: A multicenter, open-label, exploratory randomized controlled trial.

The reference data showed a trend toward worsening of the CP and Model of End-stage Liver Disease (MELD) scores for the historical control group, whereas the transplant group exhibited delayed disease progression, suggesting the efficacy of CD34 + cell therapy in preventing cirrhosis progression and improving liver reserve function.

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The type IV collagen level changes showed an increasing trend in the SOC group but was not significantly different between groups at any point ( Fig.

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