Potential impact of blood cholesterol guidelines on statin treatment in the U.S. population using interrupted time series analysis.

A significant trend change was detected in the Diabetes group ( P = 0.002), and the trajectory of 5-Year MACE Survival changed from a negative slope to a positive slope.

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Statin use Trends in statin use in 6 months increased for both the ASCVD and Diabetes groups since atorvastatin went generic in Dec 2011, with a decreasing trend for High-LDL group and a consistent trend for High-ASCVD-Risk group (Fig. 3 A). 64.68% of the ASCVD group started statins within 6 months in Dec 2011, and its slope increased from + 0.6pp to + 3.15pp per year from pre- to post-guideline, reaching 76.97% statin use in May 2016 (rosuvastatin generic date).

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Statin adherence Among statin initiators, all statin-benefit groups exhibited an increasing trend of statin adherence from Dec 2011 to May 2016 (Fig. 3 C).

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