At 5 years, a clear trend to local and locoregional recurrence was observed in patients with tumor budding (26% and 33%, respectively) and especially in patients with single-cell invasion (40% and 45%, respectively) in relation to patients without budding ( Table 3 , Figure 4 ).
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The impact of tumor budding and single-cell invasion on survival in patients with stage III/IV locally advanced oral squamous cell carcinoma- results from a prospective cohort study.
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