Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC.

In contrast, when we tested the agonistic properties of AZ’6421 in vivo, using the previously described immature female rat model 42 , we were surprised to find that AZ’6421 behaved more like AZD9496; both the 30 and 100 mg/kg doses of AZ’6421 showed a trend of increased uterine weight, similar to AZD9496 (Fig. 8b ).

also in 53,322 other papers