Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy.

5 A-B, the expression levels of the mitochondrial ETC subunits I, II, and IV showed a trend toward decrease, while the ETC subunits III and V levels remained unchanged.

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Consistent with in vivo experiments, our results demonstrated a decreasing trend in irisin levels in BV2 cells exposed to K18 fibrils (Fig. 1 H-I).

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