YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing.

When “allelic ratios” are calculated for all ATAC-seq peaks amenable to allelic analysis ( n = 790 of 2042 ChrX peaks, see “Methods”), there is a clear trend of decrease from biallelic accessibility of REs in uninduced mESCs (median ~0.50) to monoallelic accessibility in differentiated NPCs (median ~0.11) (Fig.

also in 19,460 other papers