Landscape of Baseline and Acquired Genomic Alterations in Circulating Tumor DNA with Abemaciclib Alone or with Endocrine Therapy in Advanced Breast Cancer.

A nominally significant interaction effect between the presence/absence of an alteration and efficacy of abemaciclib plus NSAI versus placebo plus NSAI was observed for EGFR , FGFR1 , CCND1 , and PIK3CA ( Fig. 3 ); however, these results should be interpreted with caution because of the exploratory nature of the analysis.

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