Copy-number variants and polygenic risk for intelligence confer risk for autism spectrum disorder irrespective of their effects on cognitive ability.

Front Psychiatry · 2024 · PMC11094536 · PMID 38751416

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nominally significantno p-value reported

We identified a nominally significant negative interaction between these genetic risk factors, implying that the impact of PRS-IQ on ASD risk is attenuated in subjects with a high burden of CNVs, irrespective of their level of cognitive ability.

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